Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1990-05-24
1992-07-28
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514970, 544309, 544312, 544313, 544315, 544317, A61K 3722
Patent
active
051339730
ABSTRACT:
The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.
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Menger, Acc. Chem. REs. 12, 111-117 (1979a).
W. Forth et al, Allgemeine und spezielle pharmakologie und toxikologie, 4th edition, 1983, p. 616.
Fendler et al, J. Chem. Soc. Perkins III, 1097 (1977).
Attwood et al, J. Phys. Chem. 74; 3529 (1970).
Medice Chem.-Pharm. Fabrik Putter GmbH & Co. KG
Shen Cecilia
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