Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

1978-12-18

1980-04-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424270, 548197, 548205, C07D27720

Patent

active

042005787

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 and R.sup.3 each are independently hydrogen, (lower)alkyl, guanidino or --(CH.sub.2).sub.p NR.sup.4 R.sup.5 ; R.sup.4 and R.sup.5 each are independently hydrogen, (lower)alkyl or phenyl; n is 2 or 3; p is 1, 2 or 3; X is NR.sup.6 or CHR.sup.6 ; R.sup.6 is cyano, nitro, SO.sub.2 Ar or SO.sub.2 (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.

REFERENCES:
patent: 4022797 (1977-05-01), Durant et al.
patent: 4072748 (1978-02-01), Durant et al.
patent: 4112234 (1978-09-01), Crenshaw et al.
Gannellin et al., Federation Proceedings, 35 (1924 (1976), Drugs of the Future, 1, 13(1976).

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