Isolated nucleic acid encoding G-protein coupled receptor (HTADX

Details Isolated nucleic acid encoding G-protein coupled receptor (HTADX Isolated nucleic acid encoding G-protein coupled receptor (HTADX

1997-01-24

1999-06-08

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 71, 435 72, 435 697, 4352523, 4353201, 536 234, 536 235, C12N 1512, C12N 1562

Patent

active

059104309

ABSTRACT:
HTADX50 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTADX50 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

REFERENCES:
patent: 5466593 (1995-11-01), Shimomura et al.
Sawzdargo et al.; "A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occurring in Close Proximity to CD22 Gene on Chromosome 19q13.1", Bioch. Biophys. Res. Comm., vol. 239, pp. 543-547 (1997).
Gerszten et al.; "Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface", Nature, vol. 368, pp. 648-651 (1994).
Oliveira et al.; "A common motif in G-protein-coupled seven transmembrane helix receptors", Journal of Computer-Aided Molecular Design, vol. 7, pp. 649-658 (1993).
Copy of Partial European Search Report of Jul. 1, 1998.

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