Regulation of gene expression

Details Regulation of gene expression Regulation of gene expression

1996-05-21

2000-02-08

Martinell, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 241, 435325, 435 11, 435 911, 800 13, 800 25, C12N 1511

Patent

active

060228636

ABSTRACT:
The present invention relates to utrons, RNA molecules which contain promoter regulatory motif(s) and DNA analogs thereof and DNA molecules that can be transcribed to produce the foregoing. In particular, the invention provides gene promoter suppressing nucleic acids which suppress transcription from a promoter of interest. In a preferred embodiment, the invention provides the TSU gene, nucleotide sequences of the TSU gene and RNA, as well as fragments, homologs and derivatives thereof. Methods of isolating TSU genes are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are also provided. In particular, the invention relates to methods for cell replacement therapy, gene therapy or organ transplantation wherein TSU nucleic acids suppress MHC class I and II gene expression, thus preventing immuno-rejection of non-autologous cells or organs. The invention also provides methods for treatment of diseases or disorders by suppression of MHC class I, MHC class II, ICAM-1, B7-1, B7-2, and/or Fc.gamma.R expression by provision of TSU function.

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