Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related c

Details Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related c Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related c

1993-11-12

1996-02-27

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142338, 5142345, 544 62, 544135, 544137, C07D41706, C07D41306, A61K 31535, A61K 3154

Patent

active

054949084

ABSTRACT:
This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

REFERENCES:
patent: 3681382 (1972-08-01), Gschwend et al.
patent: 3707364 (1972-12-01), Becke et al.
patent: 3725431 (1973-04-01), Gschwend et al.
patent: 4533731 (1985-08-01), Ibuki et al.
patent: 4549023 (1985-10-01), Ibuki et al.
patent: 4604375 (1986-08-01), Davis
patent: 5100902 (1992-03-01), Peglion
Chem Abstracts, vol. 61, 12008g-12009a, Jul. 20, 1963, A. Knoll, "Basically substitued 1,2-benisothiazoles".

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