Endothelin antagonistic peptide

Details Endothelin antagonistic peptide Endothelin antagonistic peptide

1994-06-03

1996-02-27

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, A61K 3800, A61K 3804, C07K 500

Patent

active

054948975

ABSTRACT:
A peptide derivative of the formula: ##STR1## is a novel compound having antagonism against three endothelin isopeptides. A 2-cyanotryptophan or a protected compound thereof, is an intermediate for the preparation of the endothelin antagonist.

REFERENCES:
patent: 5144918 (1992-05-01), Ishikawa et al.
Tetrahedron Letters, vol. 33, No. 1, 1992, pp.29-32, Rajesh K. Dua, et al., "Synthesis of 5-Cyano-L-Tryptophan".

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