Method for producing a microparticle

Details Method for producing a microparticle Method for producing a microparticle

1999-03-01

2000-02-08

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, 514211, 5142242, B02C 2306

Patent

active

060225645

ABSTRACT:
This invention provides a method for producing a microparticle which comprises pulverizing a solid preparation comprising a compound represented by the formula: ##STR1## wherein ring A is an optionally substituted benzene ring; R is a hydrogen atom or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is --CH(OH)-- or --CO--; k is 0 or 1; and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof and a biodegradable polymer of .alpha.-hydroxycarboxylic acid in the presence of a pulverizing auxiliary, which can provide microparticles which are less adhesive and involve less aggregation and are thus excellent in drug entrapment ratio and control of drug-release in a desired particle size.

REFERENCES:
patent: 5134122 (1992-07-01), Orsolini
patent: 5213812 (1993-05-01), Ruiz
patent: 5225205 (1993-07-01), Orsolini
patent: 5439688 (1995-08-01), Ovsolini et al.
patent: 5567431 (1996-10-01), Vert

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