Cyclic disulfonic ester cross-linking compounds

Details Cyclic disulfonic ester cross-linking compounds Cyclic disulfonic ester cross-linking compounds

1984-01-16

1990-08-21

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

556428, C07D33900

Patent

active

049507680

ABSTRACT:
Cyclic disulfonic ester bifunctional cross-linking compounds effective in treating certain types of cancers are described. Initial nucleophilic reaction with the compound produces a negatively charged sulfonic acid end-group which remains attached to the compound until the second nucleophilic crosslinking reaction occurs.

REFERENCES:
patent: 4483799 (1984-11-01), Kampfer et al.
Remers, W. A., "Antineoplastic Agents", John Wiley & Sons, New York, N.Y., 1984, pp. 69-76.
Hecht, A., "Cancer Drugs That Work", FDA Consumer, Oct., 1977, pp. 18, 20, 21.
Hayashi et al., Chemical and Pharmaceutical Bulletin, vol. 12, No. 11, 1964, pp. 1271-1272.
Leong, "Synthesis of Cyclic Methanedisulfonate Esters by the Silver Salt Method", Reed College Chemistry Library, 1972.
Engel, "Synthesis of Cyclic Methanedisulfonate by Diol Reaction Method", Reed College Chemistry Library, 1981.
McCaffrey, "Synthesis of Cyclic Methanedisulfonates: Analogues of Myleran-A Cancer Chemotherapy Compound", Reed College Chemistry Library, 1982.

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