Toxoplasma gondii antigens, the preparation thereof and the use

Details Toxoplasma gondii antigens, the preparation thereof and the use Toxoplasma gondii antigens, the preparation thereof and the use

1994-09-06

2000-02-08

Chin, Christopher L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

4241841, 4241851, 4241911, 530300, 530350, 5303871, 5303886, A61K 39012

Patent

active

060225467

ABSTRACT:
The present invention relates to the identification of Toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were identified using a high-titer rabbit anti-Toxoplasma gondii serum, and isolated.

REFERENCES:
patent: 4877726 (1989-10-01), Suzuki et al.
patent: 5429922 (1995-07-01), Sibley et al.
Koch et al Zeitschrift for die gesamte Hygiene und ihre Grenzgebiete pp. 1-10 Translation, Oct. 1989.
A. Johnson et al., Gene, vol. 85, pp. 215-220 (1989), Cloning Expression and Nucleotide Sequence of the Gene Fragment Encoding an Antigenic Portion of the Nucleoside Triphosphate Hydrolase of T. Gondii.
M.F. Cesbron-Delauw et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 7537-7541 (1989), Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii.
J. Burg et al., J. Immunol., vol. 141, pp. 3584-3591 (1989), Molecular Analysis of the Gene Encoding the Major Surface Antigen of T. Gondii.
Koch et al Zeitschrift fur die gesamte Hygiene und 1 Hre Grenzgebiete, pp. 615-617 1989 (Translation).
Ieda et al Jpn Journal of Parasitol 32:15-21, 1983.
Johnson et al Biochem & Biophysci Res Cenv 100: 934-943 1981.
Kimata et al Journal of Cell Science 88:231-239, 1987.
Koch et al Z. Gesamte Hyg Ihre Grenzgeb 35(10)615-17 1989 Characterization of monoclonal antibodies against Toxoplasma gondii. (Abstract only).
Johnson et al, Biochem. & Biophy. Res Comm 100:934-943, 1981.
Knapp et al Biotechniques Mar. 1990, 8:280.
Kasper et al J of Imm. 132:443-449.
Young et al PNAS 1983 80:1194-8.
Burg et al J Imm. 1988 141:3584-91.
S. Knapp et al., International Congress of Parasitology, Paris--France (Aug. 1990).
Johnson et al., Gene 85:215-20 (1989).
H. P. A. Hughes, Curr. Top. Microbiol. (1985) 120:105-39.
E. Handman et al., Immunol. (1980) 40:570-88.
I. Potasman et al., J. Infect. Diseases (1986) 154:650-7.
A. Decoster et al., Clin. Exper. Immunol. (1988) 73:376-82.
H.A. Ehrlich et al., Infect. Immun. (1983) 41:683-90.
S.D. Nagel and J.C. Boothroyd, j. Biol. Chem. (1989) 264:5569-76.
I. Potasman et al., J. clin. Microbiol. (1986) 24:1050-4.
J.L. Burg et al., J. Immunol. (1988) 141:3584-91.
J.B. Prince et al., Mol. Biochem. Parasitol. (1989) 34:3-14.
I. Braveny et al., Tropenmed. Parasit (1978) 29:432-4.
P. Chomczynski and N. Sacchi, Anal. Biochem. (1987) 162:156-9.
U. Gubler, Nucl. Acids Res. (1988) 16:2726.
L.S. Ozaki, et al., J. Immun. Method. (1986) 89:213-9.
Promega Biotec. Proto Blot Immunoscreening System, (1986) Technical Manual.
R.A. Young and R.W. Davis, Proc. Natl. Acad. Sci. (1983) 80:1194-8.
R. Brent and N. Ptashne, Proc. Natl. Acad. Sci. (1981) 78:4202-8.
T.V. Huynh et al. in: Glover, DNA Cloning vol. I (1985) pp. 49-78, IRL Press, Oxford.
F. Sanger et al., Proc. Natl. Acad. Sci (1977) 74:5463-7.
S. Knapp et al., BioTechniques (1990) 8:280.

Affiliated with

Also associated with

Rating

Toxoplasma gondii antigens, the preparation thereof and the use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Toxoplasma gondii antigens, the preparation thereof and the use , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Toxoplasma gondii antigens, the preparation thereof and the use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1678661