Photochemical nucleic acid-labeling reagent having a polyalkylam

Details Photochemical nucleic acid-labeling reagent having a polyalkylam Photochemical nucleic acid-labeling reagent having a polyalkylam

1987-03-18

1990-08-21

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 4, 435 6, 435188, 436 63, 436 94, 436501, 548463, 549282, 935 77, 935 78, C07H 1900, C12Q 168, C12Q 100

Patent

active

049507443

ABSTRACT:
A photochemical nucleic acid-labeling reagent of the formula ##STR1## wherein Q is a photoreactive residue of a nucleic acid-binding ligand; L is a detectable label residue; R is hydrogen, C.sub.1 to C.sub.7 -alkyl, aryl, hydroxy, or C.sub.1 to C.sub.7 -alkoxy; x is an integer from 2 through 7; and y is an integer from 3 through 10; wherein R and x, respectively, can be the same or different each time they appear in the formula. The reagent is useful in the highly efficient labeling of nucleic acids for the purpose of detection in hybridization assays.

REFERENCES:
patent: 4582789 (1986-04-01), Sheldon, III et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4617261 (1986-11-01), Sheldon, III et al.
patent: 4737454 (1988-04-01), Dattagupta et al.
Lown et al., "Bis-Intercalative Binding to DNA of Novel Bis(10-Methyl)acridinium Chlorides and its Dependence on Chain Length of Linker," Can. J. Biochem. 1987, 56(1), 1006-15.
Hansen et al., "Acridine-Psoralen Amines and their Interaction with DNA," Biochemistry, 22(21), 4878-4886, 1983.

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