Polymers derived from crosslinked polystyrenes and dextrans, the

Details Polymers derived from crosslinked polystyrenes and dextrans, the Polymers derived from crosslinked polystyrenes and dextrans, the

1988-08-22

1990-08-21

Kight, III, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

5253333, 5253336, 536 24, 536 28, 536112, C08F 3702, C08F 830, C08F 834, C08F 840

Patent

active

049507125

ABSTRACT:
These resins derived from a crosslinked styrene (co)-polymer, or from a crosslinked dextran, comprise a (co)-polymer chain which is substituted with one or more groups, which may be identical or different, belonging to the following categories: --Z--A.sub.1 ; --Z--A.sub.2 ; --Z--A.sub.1 --Z'--A.sub.2 ; --Z--A.sub.1 --A.sub.3 --A.sub.2 ; --Z--A.sub.1 --A.sub.4, where Z=spacer chain, Z'=linking chain, A.sub.1 =phosphate residue, A.sub.2 =residue of purine or pyrimidine base, A.sub.3 =sugar residue and A.sub.4 =residue of a molecule participating in the polar structure of various phospholipids. These resins are applicable for the analysis and purification of molecules of biological origin, in particular as a stationary phase in ion-exchange and affinity chromatography, especially for carrying out the fractionation of protein mixtures. Their interaction with proteins, in particular the anti-DNA and anti-phospholipid antibodies present in the serum of patients suffering from SLE, makes them applicable to operations for the selective purification of the different types of antibodies developed by lupus patients.

REFERENCES:
patent: 4659774 (1987-04-01), Webb et al.
patent: 4780504 (1988-10-01), Buendia et al.

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