Didemnins and nordidemnins

Details Didemnins and nordidemnins Didemnins and nordidemnins

1987-12-23

1990-08-21

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3700

Patent

active

049506498

ABSTRACT:
Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting acute myelocytic leukemia and acute lymphocytic leukemia.

REFERENCES:
Morishima et al., Jr. of Antibiotics, vol. XXIII, No. 5, May 1970, pp. 263-265.
Dorr et al., Clinical Pharmacology (Adult & Pediatric) (Proceedings of Amer. Soc. Clin. Oncol., vol. 5, Mar. 1986), p. 39 (No. 151).
Stewart et al., Clinical Pharmacology (Adult & Pediatric) (Proceedings of Amer. Soc. Clin. Oncol., vol. 5, Mar. 1986), p. 33 (No. 128).
Jiang et al., Cancer Chemotherapy & Pharmacology, 1983, vol. 11, pp. 1-4.

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