Recognition of oligonucleotides containing non-standard base pai

Details Recognition of oligonucleotides containing non-standard base pai Recognition of oligonucleotides containing non-standard base pai

1995-10-12

2000-03-14

Arthur, Lisa B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 935 77, 935 78, C12Q 168, C07H 2104

Patent

active

06037120&

ABSTRACT:
The disclosure describes a new method for intermolecular recognition between two molecules, where complementary oligonucleotide strands bind in aqueous solution, where these strains contain non-standard nucleobases that can pair to fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").

REFERENCES:
patent: 4921788 (1990-05-01), Deutsch
patent: 5432272 (1995-07-01), Benner
Piccirilli et al. Nature 343 (Jan. 4, 1990):33-37.
Switzer et al. Biochemistry (1993) 32:10489-10496.

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