Thieno-pyridine derivatives and therapeutic composition containi

Details Thieno-pyridine derivatives and therapeutic composition containi Thieno-pyridine derivatives and therapeutic composition containi

1976-04-14

1978-02-28

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602948C, A61K 3144, C07D40704

Patent

active

040768198

ABSTRACT:
This invention relates to thieno-pyridine derivatives having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; R.sub.2 is hydrogen or acetyl or lower alkylcarbamoyl and R.sub.3 is methyl, nitrobenzyl, chlorobenzyl, methoxybenzyl, chlorobenzoyl, trimethoxybenzoyl, pyrrolidinoacetyl, p.toluene-sulfonyl, phenylcarbamoyl, phenylthiocarbamoyl, 3-oxo-butyl, lower alkyl-carbamoyloxy, phenethyl, dichloroacetyl, 2-chlorophenoxy-2-methyl-propionyl or chlorophenyl-carbamoyl, and their pharmaceutically acceptable acid addition salts.
Said derivatives have useful anti-inflammatory properties and inhibiting effects on blood plate aggregation which make them therapeutically valuable.

REFERENCES:
patent: 3983125 (1976-09-01), Amselem
Burger, Medicinal Chemistry, Second Edition, Interscience Publishers, p. 497, (1960).

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