Microbiological modification of antibiotic A23187 esters

Details Microbiological modification of antibiotic A23187 esters Microbiological modification of antibiotic A23187 esters

1980-07-30

1981-09-01

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435893, C12P 1718, C12R 152

Patent

active

042873029

ABSTRACT:
Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.

REFERENCES:
patent: 3923823 (1975-12-01), Gale et al.
patent: 3960667 (1976-06-01), Gale et al.

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