Reduction of the severity of 3'-azido-3'-deoxythymidine-induced

Details Reduction of the severity of 3'-azido-3'-deoxythymidine-induced Reduction of the severity of 3'-azido-3'-deoxythymidine-induced

1988-06-22

1990-08-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514258, 514922, A61K 4700, A61K 31505

Patent

active

049504665

ABSTRACT:
The invention is directed to a method of inhibiting anemia caused by the administration of AZT to a patient which comprises administering to said patient an effective anemia-inhibiting amount of a combination of dipyridamole and 5-benzylacyclouridine. The invention is further directed to a pharmaceutical composition comprising as the active pharmaceutical agent a combination of dipyridamole and 5-benzylacyclouridine in association with a pharmaceutically acceptable carrier or diluent.

REFERENCES:
Chemical Abstracts 108(9):68364, El Kouni et al., 1987.
El Kouni et al., "Metabolism of Adenosine Analogues by Schistosoma Mansoni and the Effect of Nucleoside Trahsport Inhibitors", Biochemical Pharmacology, 36, 7, pp. 1099-1106, 1987.

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