Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative usefu

Details Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative usefu Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative usefu

1985-08-22

1987-11-03

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544182, 544376, 546196, 546269, 548252, 548336, 549 60, 549414, C07D30783

Patent

active

047044624

ABSTRACT:
Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivatives have been prepared. These neolignans are found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by PAF, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, toxic shock syndrome and adult respiratory distress syndrome.

REFERENCES:
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G. Buchi et al., J. Chem. Soc., 99, No. 24, pp. 8073-8075 (1977).
Y. Shizuri et al., Tet. Letters, 24, No. 45, pp. 5011-5012 (1983).
O. A. Lima et al., Chem. Abstrs., 77:101311x (1972).
J. B. Fernandes et al., Chem. Abstrs. 86:13793m (1977).
C. J. Aiba et al., Chem. Abstrs. 87:151909a (1977).
R. Braz Filho et al., Chem. Abstrs. 93:146271f (1980).

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