Cyclic ether esters of 2-substituted-6-(substituted and unsubsti

Details Cyclic ether esters of 2-substituted-6-(substituted and unsubsti Cyclic ether esters of 2-substituted-6-(substituted and unsubsti

1985-12-20

1987-11-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 68, 546 69, A61K 3148, C07D45704

Patent

active

047043954

ABSTRACT:
Cyclic ether esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.

REFERENCES:
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patent: 3228941 (1966-01-01), Bernardi et al.
patent: 3249617 (1966-05-01), Hofmann et al.
patent: 3580916 (1971-05-01), Garbrecht
patent: 4230859 (1980-10-01), Rucman
Cohen et al., J.P.E.T., 227, 327 (1983) (Cohen I).
Cohen et al., ibid, 232, 770 (1984) (Cohen II).
Lemberger et al., Life Sci., 35, 71 (1984).
Cohen et al., Drug Dev. Res., 5, 313 (1985) (Cohen IV).
Hingten et al., Abstract 37.4, Soc. for Neurosci. (13th Annual Meeting, Nov., 1983).

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