Steroid receptor modulator compounds and methods

Details Steroid receptor modulator compounds and methods Steroid receptor modulator compounds and methods

1997-10-08

1999-11-30

Huang, Evelyn Mei

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544180, 544183, 544233, 544234, 544235, 544238, 544245, 544246, 544249, 544284, 544383, 544342, 544343, 544344, 544353, C07D491052

Patent

active

059945443

ABSTRACT:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors and the method of preparing these compounds are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

REFERENCES:
patent: 2562970 (1951-04-01), Thompson et al.
patent: 2661277 (1953-12-01), Mowry
patent: 2989963 (1961-06-01), Hoffman
patent: 3095353 (1963-06-01), Surgant
patent: 3798031 (1974-03-01), Janssens et al.
patent: 3830647 (1974-08-01), Janssens et al.
patent: 3832171 (1974-08-01), Janssens et al.
patent: 3833400 (1974-09-01), Matsukawa
patent: 3928686 (1975-12-01), Poot et al.
patent: 3979394 (1976-09-01), Janssens et al.
patent: 4380634 (1983-04-01), Atkins
patent: 4479223 (1984-10-01), Fletcher
patent: 4692258 (1987-09-01), Rasberger
patent: 4943502 (1990-07-01), Terrell et al.
patent: 4956372 (1990-09-01), Kojima
patent: 5147844 (1992-09-01), Weber et al.
patent: 5693646 (1997-12-01), Jones
Database Crossfire, Beilstein, BRN=1129121: RL Atkins, D Bliss, "Substituted Coumarins and Azacoumarins. Synthesis and Flourescent Properties," J. Org. Chem.,, 43 (1978) 1975-1980.
E Bissell, A Mitchell, R Smith, "Synthesis and Chemistry of 7-Amino-4-(trifluoromethyl)coumarin and Its Amino Acid and Peptide Derivatives," J. Org. Chem., 45 (1980) 2283-2287.
GN Gromova, KB Piotrovskii, "Relative Volatility of Stabilizers for Polymer Materials," Khim Moscow, Promst., 43 (1967) 97-98.
Database Crossfire, Beilstein, BRN=880905: Sheinkman, et al, J. Org. Chem. USSR, 9 (1973) 2571-2576.
Database Crossfire, Beilstein, BRN=143474: Topsom, Journal of Organic Chemistry, Easton US, 30 (1965) 3560-3561.
Database Crossfire, Beilstein, BRN=18052: Ueda, Yakugaku Zasshi, 57 (1937) 312-316.
Database Crossfire, Beilstein, BRN=185528: Hively, et al, Anal. Chem., 27 (1955) 100-101.
Database Crossfire, Beilstein, BRN=384096: Diels, Chemische Berichte, Weinheim de, 35 (1902) 3278.
Database Crossfire, Beilstein, BRN=193508: 211894, Mosettig, Journal of the American Chemical Society, DC US, 57 (1935) 902.
Database Crossfire, Beilstein, BRN=1241334: 1682456, Ivanov et al, Bull.. Acad. Sci. USSR Div. Chem. Sci. (Engl. Transl.), 25 (1976) 2069-2071.
Database Crossfire, Beilstein, BRN=4800533, 4800630, 4804716: VA Ashwood, et al, Journal of Medicinal Chemistry, Washington US, 34 (1991) 3261-3267.
Database Crossfire, Beilstein, BRN=424721: Eastman Kodak, Chem. Abstr., 74 (1970) 32685.
Database Crossfire, Beilstein, BRN=140265: Heliodoro, Chem. Abstr., 84 (1975) 74121.
Database Crossfire, Beilstein, BRN=640834: Brown, Journal of the Chemical Society, Letchworth GB, (1964) 3132-3140.
Database Crossfire, Beilstein, BRN=390257: Liska, Journal of Medicinal Chemistry, Washington US, 15 (1972) 1177.
Database Crossfire, Beilstein, BRN=1565891: Jolidon, Helvetica Chimica Acta, Basel CH, 60 (1977) 978-1021.
Database Crossfire, Beilstein, BRN=269284: Cavallito, Journal of the American Chemical Society, DC US, 66 (1944) 1927.
M Tod, R Farinotti, G Mahuzier, I Ganry, Anal. Chim. Acta (Abstract), 217 (1989) 11-21.
AN Kost, AK Sheinkman, AN Prilepskaya, Khim. Geterotsikl. Soedin., Sb., 1: Azotsoderzhashcie Geterotsikly. Editor: S Jillers. Publisher: Oze/"Zinatne". Riga, USSR, (1967) 248-253.
G Teutsch, D Philbert, Human Reproduction, 9, Suppl. 1 (1994) 12-31.
CE Cook, MC Wani, YW Lee, PA Fail, V Petrow, Life Sci., 52 (1992) 155-162.
DW Martin, PA Mayes, VW Rodwell, "Harper's Review of Biochemistry", 19th Ed., Lange Medical Publications, Los Altos, CA., (1983) 497, 499.
LG Samsonova, RM Fofonova, RT Kuznetsova, IV Sokolova, LI Lobda, NY Vasileva, EV Ivanova, Kvantovaya Elektron (Abstract), Kiev, 41 (1992) 63-72.
X Song, J Chen, X Zhang, G Xu, Chin. Sci. Bull. (Abstract) 36 (1991) 1000-1003.
AN Fletcher, DE Bliss, Appl. Phys. 16 (1978) 289-295.

Affiliated with

Also associated with

Rating

Steroid receptor modulator compounds and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Steroid receptor modulator compounds and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Steroid receptor modulator compounds and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1674450