Cyclic urethanes useful as antiarrhythmic and antifibrillatory a

Details Cyclic urethanes useful as antiarrhythmic and antifibrillatory a Cyclic urethanes useful as antiarrhythmic and antifibrillatory a

1995-06-07

1999-11-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514326, 544369, 546209, A61K 31445, A61K 31495, C07D41314

Patent

active

059943548

ABSTRACT:
The novel cyclic urethanes, and their pharmaceutically-acceptable salts and esters, described herein which are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein (a) X is a saturated or unsaturated, 5-, 6-, or 7-membered heterocycle or carbocycle;

REFERENCES:
patent: 2802002 (1957-08-01), Gever et al.
patent: 3318878 (1967-05-01), Dunn
patent: 3415821 (1968-12-01), Davis et al.
patent: 3598812 (1971-08-01), Hoyle et al.
patent: 3839567 (1974-10-01), Rufer et al.
patent: 3906101 (1975-09-01), Hoyle et al.
patent: 4393204 (1983-07-01), Pelosi, Jr.
patent: 4543359 (1985-09-01), Ellis et al.
patent: 4689341 (1987-08-01), Diamond et al.
patent: 4705799 (1987-11-01), Gregory
patent: 4707499 (1987-11-01), Baran et al.
patent: 4713832 (1987-12-01), Pascal
patent: 4720580 (1988-01-01), Buzby et al.
patent: 4775670 (1988-10-01), Sykes et al.
patent: 4870095 (1989-09-01), Bailey
patent: 4876262 (1989-10-01), Oinuma et al.
patent: 4882354 (1989-11-01), Huang et al.
patent: 4886794 (1989-12-01), Walsh
patent: 4895867 (1990-01-01), Huang et al.
patent: 4963561 (1990-10-01), Lesher et al.
patent: 4966967 (1990-10-01), Lumma, Jr. et al.
patent: 5066662 (1991-11-01), Hobbs et al.
patent: 5086055 (1992-02-01), Walsh et al.
patent: 5091426 (1992-02-01), Pelosi
Bigger, J. T. and Hoffman, B. F., "Antiarrhythmic Drugs", Ch. 35 in Goodman and Gilman's The Basis of Pharmaceutical Therapeutics, 8th ed., ed., A. G. Gilman, pp. 840-873 (1990).
Bigger, J. T., "Antiarrhythmic Treatment: An Overview", American Journal of Cardiology, vol. 53, pp. 8B-16B, Feb. 27, 1984.
Woosley, R. L., "Antiarrhythmic Agents", in The Heart, Ch. 95, pp. 1682-1711, ed. J. W. Hurst, New York, McGraw-Hill (1990).
Woosley, R. L., "Antiarrhythmic Drugs", Annual Review. Pharmacology and Toxicology, vol. 31, pp. 427-455 (1991).
Morganroth, J. and Bigger, J. T., "Pharmacological Management of Ventricular Arrhythmias After the Cardiac Arrhythmia Suppression Trial", American Journal of Cardiology, vol. 65, pp. 1497-1503 (1990).
Goldstein, S., "Toward a New Understanding of the Mechanism and Prevention of Sudden Death in Coronary Heart Disease", Circulation, vol. 82(1): pp. 284-288 (1990).
Echt, D. S. et al. Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo: The Cardiac Arrhythmia Suppression Trial, New England Journal of Medicine, vol. 324, pp. 781-788 (1991).
Coplen, S. E. et al. "Efficacy and Safety of Quinidine Therapy for Maintenance of Sinus Rhythm After Cardioversion: A Meta-analysis" Circulation, vol. 82, pp. 1106-1116 (1990).
Swirska, A. et al., "Derivatives of 5-Piperidinomethyl-3-amino-2-oxazolidone with Expected Hypotensive Action", Acta Polon. Pharm. 23 (No. 2):93-96, 1996.
Swirska et al. Chem. Abstr. vol. 65 Entry 10575a (1966.

Affiliated with

Also associated with

Rating

Cyclic urethanes useful as antiarrhythmic and antifibrillatory a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic urethanes useful as antiarrhythmic and antifibrillatory a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic urethanes useful as antiarrhythmic and antifibrillatory a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1672923