Peptidyl compounds and their therapeutic use

Details Peptidyl compounds and their therapeutic use Peptidyl compounds and their therapeutic use

1996-05-10

1999-11-30

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 530868, 4241841, 4241851, 2609982, C07K 500, A61K 3805

Patent

active

059942932

ABSTRACT:
Dipeptidyl derivatives having a SH of acylS group and which are amides, thioamides or S(O).sub.0-2 -amides, have therapeutic utility via MMP or TNF inhibition.

REFERENCES:
patent: 5144043 (1992-09-01), Dean et al.
patent: 5214181 (1993-05-01), Morita et al.
Spatola, "Chemistry & Biochemistry of Amino Acids, Peptides, Proteins" vol. 7 (Marcell Decker Inc 1983) pp. 277-281, 338-340.
Fournie-Zaluski et al. Eur. J. Biochem. vol. 139 pp. 267-274 (1984).

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