Human keratins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 691, 4352521, 4353201, 4352523, C12Q 168, C12P 2106, C12N 1500, C12N 120

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active

059940816

ABSTRACT:
The invention provides human keratins (KERT) and polynucleotides which identify and encode KERT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KERT.

REFERENCES:
Lodish, H. et al., Molecular Cell Biology, Scientific American Books, New York, NY, pp. 1106-1116 (1995).
Fuchs, E. and D.W. Cleveland, "A Structural Scaffolding of Intermediate Filaments in Health and Disease", Science, 279: 514-519 (1998).
Fuchs, E., "Of Mice and Men: Genetic Disorders of the Cytoskeleton", Mol. Biol. Cell, 8: 189-203 (1997).
Takahashi, K. et al., "Cloning and Characterization of Multiple Human Genes and cDNAs Encoding Highly Related Type II Keratin 6 Isoforms", J. Biol Chem., 270: 18581-18592 (1995).
Takahashi, K. et al., (Direct Submission), GenBank Sequence Database (Accession L42475), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 908769; GI 908779).
Eckert, R.L. and E.A. Rorke, "The Sequence of the Human Epidermal 58-kD (#5) Type II Keratin Reveals an Absence of 5' Upstream Sequence Conservation between Coexpressed Epidernal Keratins", DNA, 7: 337-345 (1988).
Eckert, R.L. and E.A. Rorke et al., (Direct Submission), GenBank Sequence Database (Accession M21389), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 186697; GI 307082).
Lersch, R. et al., "Isolation, Sequence, and Expression of a Human Keratin K5 Gene: Transcriptional Regulation of Keratins and Insights into Pairwise Control", Mol. Cell Biol., 9: 3685-3697 (1989).
Uttam, J. et al., "The genetic basis of epidermolysis bullosa simplex with mottled pigmentation", Proc. Natl. Acad. Sci. USA, 93: 9079-9084 (1996).
Bader, B.L., et al., "Amino acid sequence and gene organization of cytokeratin No. 19, an exceptional tail-less intermediate filament protein", Embo J., 5: 1865-1875 (1986).
Lussier, M. et al., "The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment", Gene, 95: 203-213 (1990).
Savtchenko, E.S. et al., "Embryonic Expression of the Human 40-kD Keratin: Evidence from a Processed Pseudogene Sequence", Am. J. Hum. Genet., 43: 630-637 (1988).
Corden, L.D. and W.H.I. McLean, "Human keratin diseases: Hereditary fragility of specific epithelial tissues", Exp. Dermatol., 5: 297-307 (1996).
Tomic-Canic, m. et al., "Novel Regulation of Keratin Gene Expression by Thyroid Hormone and Retinoid Receptors", J. Biol. Chem., 271: 1416-1423 (1996).
Steinert, P.M. et al., "Self-assembly of Bovine Epidermal Keratin Filaments in Vitro", J. Mol. Biol., 108-547-567 (1976).

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