Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-12-03
1982-01-26
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602452T, 260239A, 424269, 424270, 424274, 546272, 542401, 542405, 542413, 542443, C07D48704, A61K 3140
Patent
active
043128718
ABSTRACT:
Disclosed are 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.6, R.sup.7 and R.sup.8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 4181733 (1980-01-01), Christensen et al.
patent: 4262009 (1981-04-01), Christensen et al.
patent: 4262010 (1981-04-01), Christensen et al.
patent: 4262011 (1981-04-01), Christensen et al.
Christensen Burton G.
Shih David H.
Arno James A.
Lee Mary C.
Mahon Frank M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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