Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1978-11-24
1981-02-10
Jiles, Henry R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546330, 546306, 546291, C07D21304, C07D21357, C07D21372, C07D21370
Patent
active
042503167
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.
REFERENCES:
patent: 3876647 (1975-04-01), Durant et al.
patent: 4060621 (1977-11-01), Durant et al.
patent: 4112234 (1978-09-01), Crenshaw et al.
C. R. Ganellin et al., Federation Proceedings, 35, 1924 (1976).
Drugs of the Future, 1, 13 (1976).
Algieri Aldo A.
Crenshaw Ronnie R.
Bristol-Myers Company
Jiles Henry R.
Lloyd Richard R.
Whittenbaugh Robert C.
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