Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1979-07-31
1982-01-26
Chan, Nicky
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26032636, 2603265D, 26034622, 26034673, 544151, 544153, 544376, 546196, 542426, 542429, 424273R, C07D31102
Patent
active
043128106
ABSTRACT:
This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) and 5,6-dehydroprostacyclin (PGI.sub.1) and 5,9.alpha.-epoxy-9-deoxy-PGF.sub.1, wherein between the position beta to the carboxy (C-2) and C-5 there is substituted an inter-o-phenylene for the ethylene chain. These novel 2,5-inter-o-phenylene-3,4-dinor-prostaglandin or prostacyclin-type compounds are useful for certain of the same pharmacological purposes as prostacyclin, particularly being smooth muscle stimulators, blood pressure depressors and platelet aggregation inhibitors. Also provided are novel intermediates therefor, namely corresponding interphenylene-containing PGF.sub.2.alpha. and 5-halo-PGI.sub.1 and 6-halo-5,9.alpha.-epoxy-9-deoxy-PGF.sub.1 compounds.
REFERENCES:
patent: 3728382 (1973-04-01), Bundy
patent: 3903131 (1975-09-01), Magerlein
patent: 3962293 (1976-06-01), Magerlein
patent: 4026909 (1977-05-01), Yankee
patent: 4029681 (1977-06-01), Smith
patent: 4123441 (1978-10-01), Johnson
patent: 4138575 (1979-02-01), Bundy et al.
Axen Udo F.
Sih John C.
Armitage Robert A.
Chan Nicky
The Upjohn Company
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