Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-02-16
1981-02-10
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548315, A61K 31415
Patent
active
042501865
ABSTRACT:
Compounds of the formula ##STR1## wherein R is 2-bromo-4,5-dihydroxy-phenyl; 3-chloro-4-hydroxy-phenyl; 4-bromo-2,5-dihydroxy-phenyl; 3,5-dihydroxy-phenyl; 5-chloro-2,4-dihydroxy-phenyl; 3-hydroxy-4-methyl-phenyl; 2,6-dibromo-4-hydroxymethyl-phenyl; 3,5-dibromo-4-amino-phenyl; 3-methylmercapto-phenyl; 3,4,5-trihydroxy-phenyl; or 3-bromo-4-fluoro-phenyl;
and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
REFERENCES:
patent: 2899426 (1959-08-01), Bloom
patent: 2938038 (1960-05-01), Hirt
patent: 3468887 (1969-09-01), Stahle et al.
patent: 3595961 (1971-07-01), Stahle et al.
patent: 4025607 (1977-05-01), Stahle et al.
Conant et al., The Chemistry of Organic Compounds 3rd Ed., p. 342, N. Y., MacMillan, 1947.
Gaida Wolfram
Hoefke Wolfgang
Koppe Herbert
Kummer Werner
Pichler Ludwig
Boehringer Ingelheim GmbH
Jiles Henry R.
Ramsuer R. W.
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