Process for the preparation of corticosteroid-21-phosphoric acid

Details Process for the preparation of corticosteroid-21-phosphoric acid Process for the preparation of corticosteroid-21-phosphoric acid

1985-11-06

1987-07-07

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, C07J 0000

Patent

active

046786090

ABSTRACT:
Steroid-21-phosphoric acids and pharmaceutically usable salts thereof of the formula III ##STR1## (in which U=H or CH.sub.3, V=H, OH, O or Hal; W=H or OH and Y=H or F) are obtained in a very pure state by reacting I ##STR2## (in which X=OH or Hal) with an organic phosphoric acid ester of the formula IVa or IVb ##STR3## (in which Z=optionally substituted alkyl and R=alkyl). The compounds II ##STR4## obtained thereby is saponified to give III and the latter, if appropriate, is neutralized to give the salt. Compounds II are new.

REFERENCES:
patent: 2870177 (1959-01-01), Conbere et al.
patent: 3048581 (1962-08-01), Fried et al.
patent: 3053834 (1962-09-01), Fried et al.

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