Nucleotide derivative

Details Nucleotide derivative Nucleotide derivative

1985-10-30

1989-03-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, 536 27, 536 28, C07H 1910, C07H 1200

Patent

active

048165697

ABSTRACT:
A nucleotide of the formula [IV] shown below: ##STR1## wherein: X is hydrogen or --CO--(CH.sub.2).sub.n --CO--R.sup.3 ; each of m and n is an integer up to 20; R.sup.0 is a protective group of a phosphoric acid group, R.sup.1 is hydrogen or a protective group for a 5'-hydroxyl group, R.sup.2 is hydrogen or a protective group for an amino group, R.sup.3 is a carrier having an amino group as the functional group and bound at this functional group in this compound, Y is oxygen atom (--0--) or an imino group (--NH--). This nucleotide, when the X is --CO--(CH.sub.2).sub.n --CO--R.sup.3, has a carrier (R.sup.3) through a spacer (--CO--(CH.sub.2).sub.m --CO--) on extension from the amino group of deoxycytidine and therefore can be used as the starting material, namely the resin, for synthesizing a 3'-aminated oligonucleotide according to the solid phase method.

REFERENCES:
patent: 4086417 (1978-04-01), Ishida et al.
patent: 4297347 (1981-10-01), Katsunuma
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4417046 (1983-11-01), Hsiung

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