Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-28
1994-10-11
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
552653, C07D30733
Patent
active
053548728
ABSTRACT:
A process for synthesizing (23S,25R)-calcitriol lactone and related Vitamin D analogs comprises reacting protected enantiomerically pure glycidol or 2-alkylglycidol with protected De-A,B-8.beta.-hydroxy-24-nor-cholan-23-al, removing the protective groups from the epimeric product mixture and separating the epimers, to give a hydrindane tetrol product, followed by oxidation and protection of the hydrindane tetrol product, reacting the tetrol product with the lithium salt of (3S)-(3.alpha.,5.beta.,Z)-2-(2-methylene-3,5-bis-((1,1-dimethylethyl)dimet hylsilyloxy)cyclohexy lidene)ethyl diphenyl phosphine oxide and removing the final protective groups. Certain intermediate compounds also show biological activity as angiostatic agents.
REFERENCES:
Seino et al., S. Drugs of the Future, vol. 17, pp. 655-659 (1992).
Hatakeyama et al., J. Chem. Soc., Chem. Commun., pp. 1229-1231 (1992).
Yamamoto et al., J. Org. Chem., vol. 57, pp. 33-39 (1992).
Johnson et al. J. Org. Chem., vol. 50, pp. 2598-2600 (1985).
Wovkulich et al., J. Org. Chem., vol. 48, pp. 4433-4436 (1983).
Alcon Laboratories Inc.
Ivy C. Warren
Owens A. A.
Ryan Patrick M.
LandOfFree
Process for preparation of calcitriol lactone and related interm does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparation of calcitriol lactone and related interm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of calcitriol lactone and related interm will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1659674