Process for making pure S-timolol hemihydrate

Details Process for making pure S-timolol hemihydrate Process for making pure S-timolol hemihydrate

1992-07-08

1994-10-11

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D41704

Patent

active

053548604

ABSTRACT:
A process for preparing S-(-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazol e hemihydrate, i.e. S-timolol hemihydrate, wherein the compound is crystallized in optically pure form as the hemihydrate from a mixture containing an organic solvent, water and S-timolol base. This process can be used in the purification of S-timolol, especially for the removal of the corresponding R-enantiomer.

REFERENCES:
patent: 3657237 (1972-04-01), Weinstock
patent: 4628111 (1986-12-01), Mashiba et al.
patent: 4752478 (1988-06-01), Bondi et al.
March, Advanced Organic Chemistry, 2d ed (1977), pp. 110-111.
CAS Registry Handbook, Number Section, 1984, p. 2480 RM, Registry No. 91524-16-2.
"Nio-Pyrenol," Chemical Abstracts, Chemical Substance Index, vol. 106, p. 6752 CS, Jan.-Jun. 1987.
Chemical Abstract, vol. 106, No. 2, Jan. 12, 1987, p. 277 Abstract 93 70 k, Bundi et al.
Ullmann's Encyclopedia of Industrial Chemistry, Fifth, Completely Revised Edition, (1987) vol. A8, Wolfgang Gerhartz et al. "Coronary Therapeutics To Display Technology," pp. 6-7.
Merck Index, 11th ed. (1989), p. 1488, Budavari, editor.

Affiliated with

Also associated with

Rating

Process for making pure S-timolol hemihydrate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making pure S-timolol hemihydrate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making pure S-timolol hemihydrate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1659580