Amino substituted thienothiopyran derivatives, composition conta

Details Amino substituted thienothiopyran derivatives, composition conta Amino substituted thienothiopyran derivatives, composition conta

1987-02-27

1989-03-28

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540596, 546197, 546256, 546270, 548526, 549 23, A61K 3138, C07D49504

Patent

active

048164747

ABSTRACT:
Disclosed are compounds of the formula ##STR1## wherein A represents the divalent radical --S--CR.sub.4 .dbd.CR.sub.5 -- in which R.sub.4 and R.sub.5 independently represent hydrogen or lower alkyl; R.sub.1 represents hydrogen, lower alkyl or aryl-lower alkyl; R.sub.2 represents hydrogen, lower alkyl or aryl-lower alkyl; or R.sub.1 and R.sub.2 combined represent alkylene of 4 to 6 carbon atoms; R.sub.3 represents hydrogen or lower alkyl; an S-oxide thereof; or a pharmaceutically acceptable salt thereof; which are useful as presynaptic dopamine receptor agonists for the treatment of central nervous system disorders; processes for preparing same; and pharmaceutical compositions comprising said compounds.

REFERENCES:
D. Binder, et al., Arch. Pharm (Weinheim) 318, pp. 70-78 (1985).
P. Cagniant et al., Bull. Soc. Chim. France 1966, pp. 2172-2179.
G. S. Ponticello, et al., J. Med. Chem. 30 pp. 591-597 (1987).
P. Cagniant et al., Eur. J. Med. Chem. -Chim. Thera. 1980 pp. 439-447.
Aldrich Catalog Handbook of Fine Chemicals (1981-82) pp. 226, 609, 616, 660.
Blicke et al., J. Am. Chem. 68 (1946) pp. 1934-1936.
Shirley et al., J. Med. Chem 9 (1966) pp. 607-609.

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