Stable formulation of biologically active proteins for parentera

Details Stable formulation of biologically active proteins for parentera Stable formulation of biologically active proteins for parentera

1985-09-26

1989-03-28

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 856, A61K 3702, A61K 4502

Patent

active

048164402

ABSTRACT:
A pharmaceutical composition containing IL-2 or IFN-.beta. dissolved in a suitable carrier medium at pH 7.0 to 8.0 stabilized with sodium laurate is suitable for parenteral injection into humans or animals. This formulation may be prepared by adding to either protein, after its recovery from a transformed organism, an effective amount of sodium laurate at a pH of 9 to 9.5 and then adjusting the pH of the formulation to between 7.0 and 8.0.

REFERENCES:
patent: 3658970 (1972-04-01), Carroll
patent: 3667929 (1972-06-01), Fleming, Jr.
patent: 4331653 (1982-05-01), Brown et al.
patent: 4450103 (1984-05-01), Konrad et al.
patent: 4462940 (1984-07-01), Hanisch et al.
patent: 4604377 (1986-08-01), Fernandes et al.
Wang et al., J. Parenteral Drug Assoc., 34, 452-462 (1980).

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