Using imidazolyl tetrahydronaphthalene carboxylic acids to inhib

Details Using imidazolyl tetrahydronaphthalene carboxylic acids to inhib Using imidazolyl tetrahydronaphthalene carboxylic acids to inhib

1993-02-09

1994-10-11

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514400, 514822, A61K 31415

Patent

active

053547705

ABSTRACT:
A restenosis inhibiting agent for the treatment or prevention of restenosis after percutaneous transluminal coronary angioplasty which comprises a pharmaceutically effective amount of a compound of the following general formula or a pharmaceutically acceptable salt thereof as an active ingredient: ##STR1## wherein R is an imidazolyl group, a thiazolyl group or a pyridyl group, n is an integer of 1 or 2, and m is an integer of 1 to 4.

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patent: 4955878 (1990-09-01), See et al.
Patent Abstracts of Japan, vol. 11, No. 13 (C-397)[2460], Jan. 14, 1987.
R. Moroi et al., "Improvement in ischemic myocardial metabolism by 6-(1-imidazolylmethyl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid hydrocholoride hemihydrate(DP-1904), a thromboxane A2 synthetase inhibitor, on the isolated guinea-pig heart as studied by 31P NMR", Journal of Pharmaceutical Science, vol. 76, No. 11, Nov. 1987, p. 164, abstract No. H06-W-05.
Liu et al., "Restenosis After Coronary Angioplasty--Potential Biologic Determinants and Role of Intimal Hyperplasia," vol. 79, No. 6 (Jun. 1989).
Mickelson, JK American Heart Journal 113(6):1345-1352 (1987).
Cox, Jafna L. Canadian J. Cardiology 4(4):201-210 (1988).

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