Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d

Details Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d

1993-11-17

1994-10-11

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546312, 546310, 546309, 546307, 546289, 546297, 514349, 514344, C07D21302, A61K 3144

Patent

active

053547632

ABSTRACT:
The compounds of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl;

REFERENCES:
patent: 4390701 (1983-06-01), Algieri et al.
patent: 4673747 (1987-06-01), Nohara et al.
Tietze, et al., Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides, Chem. Ber., 124, p. 1215, 1991.
Tietze, et al., Conjugation of p-Aminophenyl Glycosides with Squaric Acid Diester to a Carrier Protein and the Use of Neoglycoprotein in the Histochemical Detection of Lectins, Bioconjugate Chem., 2, p. 148, 1991.
Ehrhardt, et al., Amide und Thioamide der Quadratsaure: Synthese und Reaktionen, Chem. Ber., 110, p. 2506, 1977.
Neuse, et al., Amidierung von Quadratsaure-estern, Liebigs Ann. Chem., p. 619, 1973.

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