Pyrrolopyrimidines, their production and use

Details Pyrrolopyrimidines, their production and use Pyrrolopyrimidines, their production and use

1993-04-14

1994-10-11

Shaw, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544250, A61K 31505, C07D48704

Patent

active

053547543

ABSTRACT:
A compound of the formula (I): ##STR1## wherein the ring A is a pyrrole ring which may be hydrogenated, X is an amino group, a hydroxyl group or a mercapto group, Y is a hydrogen atom or a hydroxyl group, --COOR.sup.1 and --COOR.sup.2 may be the same or different and are a carboxyl group which may be esterified, --B-- is a divalent heterocyclic group or a lower alkylene group each of which may be substituted, and Z is a straight C.sub.2-4 divalent group which may be substituted, or its salt, a method for the production of the same and an antitumor agent containing the same.

REFERENCES:
patent: 4946846 (1990-08-01), Nomura et al.
patent: 4997838 (1991-03-01), Akimoto et al.
patent: 5028608 (1991-07-01), Taylor et al.
John M. Venditti in "Cancer Treatment Report" vol. 67, 767-772 (1983).
Experimental Evaluation of Antitumor Drugs in the U.S.A. and U.S.S.R. and Clinical Correlations, p. 34.
Journal of Medicinal Chemistry, 34, 555-560, 1991, Miwa et al.
Journal of Medicinal Chem., vol. 13, 1970, Weinstock et al., "Folic Acid Analogs, II", pp. 995-997, 1970.
Journal of Medicinal Chem., vol. 28, 1985, Taylor et al., "Synthesis of the Antileukemic Agents 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-Tetrahydroaminopterin", pp. 914-921; 1985.

Affiliated with

Also associated with

Rating

Pyrrolopyrimidines, their production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolopyrimidines, their production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolopyrimidines, their production and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1658774