Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-09-17
1996-07-30
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 530325, 530327, 530326, 514 15, 514 16, A61K 3800, C07K 706, C07K 708, C07K 710
Patent
active
055411614
ABSTRACT:
This invention relates to peptide derivatives which are useful anticoagulant agents.
REFERENCES:
patent: 4654302 (1987-03-01), Fritz et al.
patent: 4668662 (1987-05-01), Tripier
patent: 4767742 (1988-08-01), Dodt et al.
patent: 4791100 (1988-12-01), Kramer et al.
Maraganore, et al, "Anticoagulant Activity of Synthetic Hirudin Peptides", J. Biol. Chem., 264, 8692-8698, 1989.
Krstenansky, et al, C-Terminal Peptide alcohol, acid and amide analogs of desulfato hirudin 54-65 as antithrombin agents, Thrombosis Research, 54, 319-325, 1989.
Mao, et al, Interaction with thrombin: Indendification of a minimal binding domain of hirudin that inhibits clotting activity, Biochemistry, 27, 8170-8173, 1988.
Chemical Abstracts 52:21222 abstracting F. Markwardt, Z. Physiol. Chem. 306, 147-156 (1957).
Dodt, J., et al., FEBS Letters 165(2), 180-84 (1984).
Chang, J-y., et al., FEBS Letters 164(2), 307-313 (1983).
Derwent Abstract 86-162802/26, W. German Applic. No. 3445517, published Jun. 19, 1986, Gen-Bio Tec Ges Gen, assignee.
Dodt, J., et al., Biol. Chem. Hoppe-Seyler 366, 379-385 (1985).
Badgy, D., et al., Biol. Chem. Hoppe-Seyler 366, 379-385 (1985).
Pilat, M. J. P., et al., Fed. Proc. 45(6), 1494, 76th Annual Meeting, ASBC, Jun. 8-12 (1986).
Krstenansky, J. L., et al., FEBS Letters 211(1), 10-16 (1987).
Mao, S. J. T., et al., Anal. Biochem. 161, 514-518 (1987).
Cram, D. J., et al., Organic Chemistry, 2nd Edition, McGraw Hill, p. 609 (1964).
Owen, T. J., et al., J. Med. Chem., 31, 1009-1011 (1988).
Minar, E., et al., Klin Wochenschr Feb. 15;63(4):190-1 (1985) [abstract of].
Markwardt, F., et al., Thromb. Haemostasis, 52(2), 160-3 (1984) [abstract of].
Markwardt, F., et al., Thromb Haemost Jun. 28;47(3):226-9 (1982) [abstract of].
Markwardt, F., et al., Thromb Haemost Jun. 28;49(3):235-7 (1983) [abstract of].
Bajusz, S., et al., Proc. 18th European Peptide Symposium, 473-476 (1984).
Krstenansky et al., Biochim. Biophys. Acta 957, 53-59 (1988).
Sturzebecher, The Thrombin (R. Machovich, Ed.) vol. 1, 131-160, CRC Press, Boca Roton, FL (1984).
Hruby, V., Life Sciences 31, 189-199 (1982).
Krstenansky John L.
Mao Simon J. T.
Chan Christina Y.
Marshall S. G.
Merrell Pharmaceuticals Inc.
Payne T. Helen
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