Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-12-13
1996-07-30
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 795, 436530, 436534, 436815, 5303879, 5303885, 5303891, G01N 33569, C07K 1614
Patent
active
055410774
ABSTRACT:
A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organism, particularly the heat shock protein hsp 90 of Sacchromyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.
REFERENCES:
patent: 4806465 (1989-02-01), Buckley et al.
Matthews et al, "Isolation of Immunodominant Antigens from Sera of Patients with Systemic Candidiasis and Characterization of Serological Response to Candida albicans", J. Clin. Microbiol., 25(2):230-237 (Feb. 1987).
Matthews et al, "Diagnosis of Systemic Candidiasis by an Enzyme-Linked Dot Immunobinding Assay for a Circulating Immunodominant 47-kilodalton Antigen", J. Clin. Microbiol., 26(3):459-463 (Mar. 1988).
Dragon et al, "The Genome of Trypanosoma cruzi contains a Constitutively Expressed, Tandemly Arranged Multicopy Gene Homologous to a Major Heat Shock Protein", Mol. Cell. Biol. 7(3):1271-1275 (Mar. 1987).
Matthews and Burnie, "Cloning of a DNA sequence encoding a major fragment of the 47 kilodalton stress protein homologue of Candida albicans", FEMS Microbiol. Letters, 60:25-30 (Jul. 1, 1989).
Burnie et al, Lancet "47 KD antigen of Candida albicans", pp. 1155, 18 May 1985.
Farrelly et al, "Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerivisiae", The Journal of Biological Chemistry, 259(9):5745-5751, 10 May 1984.
Matthews et al, "Characterisation and cellular localisation of immunodominant 47 KDa antigen of Candida albicans", Journal of Medical microbiology, 27:227-232, 1988.
Neale et al, "The immunochemical characterisation of circulating immune complex constituents in Candida albicans osteomyelitis by isoelectric focusing, immnoblot and immunoprint", Aust. NZ. J. Med., 17:201-208, 1987.
Matthews et al., "Immunoblot Analysis of the Serological Response in Systemic Candidosis", Lancet, pp. 1415-1418, 22/29, Dec. 1984.
Burnie James P.
Matthews Ruth C.
Ceperley Mary E.
The Victoria University of Manchester
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