Methods for screening factorial chemical libraries

Details Methods for screening factorial chemical libraries Methods for screening factorial chemical libraries

1992-04-29

1996-07-30

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 71, 436501, 436518, 530333, 530334, G01N 3353, G01N 33545

Patent

active

055410618

ABSTRACT:
A method and library for determining the sequence of monomers in a polymer which is complementary to a receptor. The method provides for formation of pooled (6) and separate (10, 12) products. Separate products are subjected only to subsequent pooled coupling steps. Each pooled product is subsequently divided for formation of pooled and separate products. The resulting polymer library includes groups of polymer products. A first group of products (42) is used to identify the monomer at a first location in a polymer that is complementary to a receptor. A second group of products (44) is used to identify the monomer at a second location in a polymer that is complementary to a receptor.

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