Surgery – Truss – Pad
Patent
1992-01-17
1994-10-11
Pfaffle, K. M.
Surgery
Truss
Pad
128664, 128665, 606 3, 250574, 356 39, 356 51, 356317, A61B 600
Patent
active
053537904
ABSTRACT:
A method and apparatus for the determination of bilirubin concentration in tissue such as skin, particularly neonatal skin. Light reflected from the skin under test is analyzed to determine bilirubin concentration in the skin, corrected for maturity-dependent optical properties of the skin, the amount of melanin in the skin and the amount of blood in the skin. Reflected red to infrared light is used to determine maturity-dependent optical properties, reflected red light is used to determine melanin content, and reflected yellow-orange light is used to determine the amount of blood in the skin. Then, these quantities are used, in combination with reflected blue light, to calculate cutaneous bilirubin concentration.
REFERENCES:
patent: 3569721 (1971-03-01), Goldberg et al.
patent: 3874794 (1975-04-01), Schmitt et al.
patent: 4029085 (1977-06-01), DeWitt et al.
patent: 4267844 (1981-05-01), Yamanishi
patent: 4423736 (1984-01-01), DeWitt et al.
patent: 4852025 (1989-07-01), Herpichbohm
patent: 4856527 (1989-08-01), Karcher et al.
patent: 4997769 (1991-05-01), Lundsgaard
patent: 5172693 (1992-12-01), Doody
patent: 5259382 (1993-11-01), Kronberg
Electronics Engineers' Handbook, FIG. 11-5 "Spectrum of a typical clear mercury lamp", 1982.
Brochure, "Conference on Lasers and Electro-Optics 1990 Technical Digest Series vol. 7," distributed by Optical Society of America, May 21-25, 1990 (Anaheim, Calif.).
Brochure, "Conference on Lasers and Electro-Optics 1991 Technical Digest Series vol. 10," distributed by Optical Society of America, May 12-17, 1991 (Baltimore, Md.).
Alexander, et al., "Determining Skin Thickness with Pulsed Ultrasound," The Journal of Investigative Dermatology, 72(1):17-19, 1979.
Anderson, et al., "The Optics of Human Skin," The Journal of Investigative Dermatology, 77(1):13-19, 1981.
Andreozzi, G. M., "New Methods for the Diagnosis of Vasculopathies: Reflexion Light Rheography and Transcutaneous Oximetry," Cardiologia, 32(11):1431-1439, Nov. 1987.
Ballowitz, et al., "Spectral Reflectance of the Skin," Biology of the Neonate, 15:348-360, 1970.
Blois, M. S., "On the Spectroscopic Properties of Some Natural Melanins," The Journal of Investigative Dermatology, 47(2):162-166, 1966.
Bohren et al., "Ch. 1, Introduction," Ch. 9, Classical Theories of Optical Constants, Ch. 10, Measured Optical Properties, Absorption and Scattering of Light by Small Particles, 1983.
Boulnois, J. L., "Photophysical Processes in Recent Medical Laser Developments: a Review," Lasers in Medical Science 1(1)47-66, 1986.
Burgeson, R. E., "The Collagens of the Skin," Curr. Probl. Derm., 17:61-75, (Karger, Basel 1987).
Carr, K., "Integrating Sphere Flux Calculations," Technical Notes, by Labsphere, No. 1, Sep. 1, 1988.
Cheong, et al., "A Review of the Optical Properties of Biological Tissues," IEEE Journal of Quantum Electronics, 26(12):2166-2185, Dec. 1990.
Engel, et al., "Effect of race and other variables on transcutaneous bilirubinometry," Pediatric Research, 15:543, 1982.
Flock, et al., "Monte Carlo Modeling of Light Propagation in Highly Scattering Tissues- I: Model Predictions and Comparisons with Diffusion Theory," IEEE Transactions on Biomedical Engineering, 36(12):1162-1168, Dec. 1989.
Hannemann, et al., "Neonatal Serum Bilirubin from Skin Reflectance," Pediatric Research, 12(3):207-210, Mar. 1978.
Hannemann, R. E., "Evaluation of the Minolta Bilirubin Meter as a Screening Device in White and Black Infants," Pediatrics, 69(1):107-109, Jan. 1982.
Hegyi, et al., "Transcutaneous Bilirubinometry II, Dermal Bilirubin, Kinetics during Phototherapy," Pediatric Research, 17(11):888-891, 1983.
Hegyi, T., "Transcutaneous Bilirubinometry in the Newborn Infant: State of the Art, Journal Clinical Monitoring, 2(1):53-58, Jan. 1986.
Hegyi, et al., "Transcutaneous Bilirubinometry. I. Correlations in Term Infants," The Journal of Pediatrics, 98(3):454-457, 1983.
Henyey, et al., "Diffuse Radiation in the Galaxy," The Astrophysical Journal, 93:70-83, Jan.-May, 1941.
Jacques, et al., "Modeling Optical and Thermal Distributions in Tissue During Laser Irradiation," Lasers in Surgery and Medicine, 6:494-503, 1987.
Jacques, et al., "Angular Dependence of HeNe Laser Light Scattering by Human Dermis," Lasers in the Life Sciences, 1(4):309-333, 1987.
Jacques, S. L., "Simple Theory, Measurements, and Rules of Thumb for Dosimetry During Photodynamic Therapy," SPIE, vol. 1065 (Photodynamic Therapy: Mechanisms), 100-108, 1989.
Jacques, S. L., "Time-Resolved Reflectance Spectroscopy in Turbid Tissues," IEEE Transactions on Biomedical Engineering, 36(12):1155-1161, Dec. 1989.
Jacques, S. L., "The Role of Skin Optics in Diagnostic and Therapeutic Uses of Lasers," Lasers in Dermatology, Laser Biology Research Laboratory, University of Texas, 1-21, 1989.
Jacques, et al., "The Melanosome: Threshold Temperature for Explosive Vaporization and Internal Absorption Coefficient During Pulsed Laser Irradiation," Photochemistry and Photobiology, 53(6):769-775, 1991.
Johnson, et al., "Development of Human Embryonic and Fetal Dermal Vasculature," Developing Human Dermal Vasculature, 93(2):10S-17S, Aug. 1989.
Kapoor, et al., "Uptake and Release of Bilirubin by Skin," Biochem. J., 136:35-43, 1973.
Kato, et al., "Early Detection of Lung Cancer by Means of Hematoporophyrin Derivative Fluorescence and Laser Photoradiation," Clinics in Chest Medicine, 6(2):237-253, Jun. 1985.
Katzir, A., "Optical Fibers in Medicine," Scientific American, 260(5):120-125, May 1989.
Keijzer, et al., "Light Distributions in Artery Tissue: Monte Carlo Simulations for Finite-Diameter Laser Beams," Lasers in Surgery and Medicine, 9(2):148-154, 1989.
Kenny, et al., "Transcutaneous Bilirubin Monitoring of Newborns," Annals of the New York Academy of Sciences, 428:251-262, 1984.
Knudsen, et al., "Skin Color and Bilirubin in Neonates," Archives of Disease in Childhood, 64:605-609, 1989.
Kollias, et al., "Spectroscopic Characteristics of Human Melanin in Vivo," The Journal of Investigative Dermatology, 85(1):38-42, 1985.
Kollias, et al., "Absorption Mechanisms of Human Melanin in the Visible, 400-720 nm," J. Inves. Derm., 89(4):384-388, 1987.
Kopola, et al., "A Skin Erythema Meter," SPIE, 1201 Optical Fibers in Medicine (V1990), 345-352, 1990.
Kortum, G. F., Reflectance Spectroscopy, Principals, Methods, Applications, Springer-Verlag New York, Inc., 25-37, 1969.
Krauss, et al., "Skin Reflectance in the Newborn Infant," Pediatric Research, 10:776-778, 1976.
Maisels, M. J., "Neonatal Jaundice," Seminars in Liver Disease, 8(2):148-162, May 1988.
Marchesini, et al., "Extinction and Absorption Coefficients and Scattering Phase Functions of Human Tissue in vitro," Applied Optics, 28(12):2318-2324, Jun. 1989.
Millington et al., "CH. 3, The Skin in Depth," Ch. 4, Mechanical Properties of Skin" and Ch. 5, Mechanical, Thermal and Electrical Properties," Skin, 48-142, 1983.
Montagna et al., "Ch. 2, The Epidermis," and Ch. 3, Other Cells in the Epidermis," The Structure and Function of Skin, Third Edition, 18-95, 1974.
Nahas, G., "Spectrophotometric Determination of Hemoglobin and Oxyhemoglobin in Whole Hemolyzed Blood," Science, 113:723-724, Jun. 22, 1951.
Patterson, et al., "Quantitative Reflectance Spectrophotometry for the Non-Invasive Measurement of Photosensitizer Concentration in Tissue During Photodynamic Therapy," SPIE (vol. 1065) Photodynamic Therapy: Mechanisms, 115:122, 1989.
Pettit, et al., "Excimer Laser Induced Autofluorescence from Arteriosclerotic Human Arteries," Lasers in Life Sciences, 3(4):205-215, 1990.
Prahl, et al., "A Monte Carlo Model of Light Propagation in Tissue," Dosimetry of Laser Radiation in Medicine and Biology, SPIE series, IS5:102-111, 1988.
Prahl, S. A., "Light Transport in Tissue," Dissertation (UMI Dissertation Services), Degree Date 1988, printed 1992.
Rosen, et al., "Immediate Pigment Darkening: Visual and Reflectance Spectrophotometric Analysis of Action Spectrum," Photochemistry and Photobiology, 51(5):583-588, 1990.
Rubaltelli, et al., "The Effect of Light on Cutaneous Bilirubin," Biol. Neonate, 18:457, 1971.
Saidi, et al., "Optical Fiber
Jacques Steven L.
Oelberg David G.
Saidi Iyad
Board of Regents , The University of Texas System
Pfaffle K. M.
LandOfFree
Method and apparatus for optical measurement of bilirubin in tis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for optical measurement of bilirubin in tis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for optical measurement of bilirubin in tis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1652475