Process for the preparation of 3-cyano-4-aryl-pyrroles

Details Process for the preparation of 3-cyano-4-aryl-pyrroles Process for the preparation of 3-cyano-4-aryl-pyrroles

1988-05-19

1990-03-27

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546281, 548517, 548527, 548561, C07D20720, C07D207323

Patent

active

049122290

ABSTRACT:
A process for the preparation of a 3-cyano-4-aryl-pyrrole of the formula ##STR1## in which Ar is optionally substituted heteroaryl or aryl, which comprises (a) reacting an .alpha.-cyanoacrylic acid derivative of the formula ##STR2## in which R.sup.1 is amino or alkoxy, with an isocyanoacetic acid ester of the formula ##STR3## in which R.sup.2 is alkyl, in the presence of a base thereby to produce a .DELTA..sup.2 -pyrroline-2-carboxylic acid derivative of the formula ##STR4## in which X represents hydrogen or an equivalent of an inorganic or organic cation,
and (b) oxidatively decarboxylating the .DELTA..sup.2 -pyrroline-2-carboxylic acid. The end products are known fungicides and the intermediates IVa are new and themselves fungicidally active.

REFERENCES:
patent: 4680413 (1987-07-01), Genda et al.
patent: 4705801 (1987-11-01), Martin et al.
patent: 4709053 (1987-11-01), Martin

Affiliated with

Also associated with

Rating

Process for the preparation of 3-cyano-4-aryl-pyrroles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 3-cyano-4-aryl-pyrroles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 3-cyano-4-aryl-pyrroles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1652047