Process of preparing 2-azido-2-deoxyarabinofuranosyl halides

Details Process of preparing 2-azido-2-deoxyarabinofuranosyl halides Process of preparing 2-azido-2-deoxyarabinofuranosyl halides

1980-06-03

1982-03-23

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536122, 536 23, 536 24, 536 18, C07H 502, C07H 504

Patent

active

043213669

ABSTRACT:
Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido,2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2'-azido group to a 2'-amino group and, if desired, alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group.

REFERENCES:
patent: 3496196 (1970-02-01), Suami et al.
patent: 3501456 (1970-03-01), Shen
patent: 4156776 (1979-05-01), Mufte et al.
patent: 4181795 (1980-01-01), Whistler

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