2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing in

Details 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing in 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing in

1985-09-03

1990-03-27

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548348, 548491, A61K 31415, C07D40304

Patent

active

049121251

ABSTRACT:
Compounds of the formula ##STR1## wherein each R is hydrogen or one R is hydrogen and the other is lower alkyl, R.sub.1 is hydrogen, lower alkyl, aryl, aralkyl or lower carboalkoxy, R.sub.2 is hydrogen or lower alkyl, and the ring A is unsubstituted or substituted by lower alkyl, lower alkoxy, halo or trifluoromethyl, and pharmaceutically acceptable salts thereof, their preparation, pharmaceutical compositions and the uses thereof, such as .alpha..sub.2 -adrenergic blocking agents, e.g. antidepressants, cognition enhancers and appetite supressants, and as intraocular pressure reducing agents are disclosed.

REFERENCES:
patent: 4598086 (1986-07-01), Bigg et al.
Chemical Abstracts, 103: 87877h (1985) [Japan Kokai 60,58,976, 4/5/85].
Abstract of EP No. 141,686, May 15, 1985.
Abstract of FR No. 2,550,532, Feb. 15, 1985.
Tetrahedron Letters, vol. 22, No. 48, pp. 4839-4842, (1981).

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