Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1989-06-26
1990-03-27
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514422, 514423, A61K 3140, A61K 31675
Patent
active
049120964
ABSTRACT:
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an antidepressant drug such as lithium, over a prolonged period of treatment.
REFERENCES:
Deicken, R. F., "Captopril Treatment of Depression", Biol. Psychiatry, 1986; 21:1425-1428.
Zubenko, G. S., "Mood-Elevating Effect of Captopril in Depressed Patients", Am. J. Psychicatry 141: 110-11, 1984.
Germain, L. et al., "Treatment of Recurrent Unipolar Major Depression with Captopril", Biol. Psychiatry, 1988; 23:637-641.
Giardina, W. J. et al., "Positive Effects of Captopril in the Behavioral Despair Swim Test", Biol. Psychiatry 1989; 25:695-702.
Bosio, A. et al., "Antidepressant Activity of ACE-Inhibitors", TIPS, vol. 8, pp. 329-330, 1987 (Abstracts of 141st Annual Meeting of the American Psychiatric Assoc., Montreal, Canada, May 7-12, 1988).
E. R. Squibb & Sons Inc.
Friedman Stanley J.
Rodney Burton
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