Methods for increasing extracellular adenosine and for stabilizi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 46, 514821, 514822, 514824, 514825, 514861, 514885, 514886, A61K 3170

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active

049120921

ABSTRACT:
Methods for increasing extracellular concentrations of adenosine for the prophylactic or affirmative treatment of diseases of the immune, nervous, cardiac, and vascular systems involving admimistering to a patient purine nucleoside and purine nucleoside-related analogs which increase extracellular adenosine concentration, and methods for stabilizing mast cells by the suppression of mast cell activation using such compounds.

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patent: 4322806 (1982-06-01), Atsumi
patent: 4432990 (1984-02-01), Robinson
patent: 4575498 (1986-03-01), Holmes
G. Shaw et al, "Purines, Pyrimidines and Imidazoles. Part 50 . . . ", J.C.S. Perkin I, 1415 (1979).
S. S. Matsumoto et al, "Adenine Nucleotide Degradation . . . ", J. Biol. Chem., 254, 18, 8956 (9/25/79).
R. C. Willis et al, "Partial Phenotype Correction . . . ", J. Biol. Chem., 259, 12, 7842 (6/25/84).
S. E. Mitsos et al, "Protective Effects of AICAriboside . . . ", Pharmocology, 31, 121 (1985).

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