Production of (-)trans-2,3-epoxysuccinic acid by fermentation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435254, 435911, 435913, 435916, 435932, C12P 1702, C12N 114

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active

050155792

ABSTRACT:
A method for producing (-)trans-2, 3-epoxysuccinic acid, which can be used as a good starting material for the sythesis of optically active compounds such as optically specific single .beta.-lactam antibiotics, characterized in that filamentous fungi capable of producing (-)trans-2,3-epoxysuccinic acid are cultured in liquid medium while either ammonia, sodium hydroxide or potassium hydroxide is added to maintain the culture medium in a pH range of 5.0 to 7.5 throughout the culturing period.

REFERENCES:
patent: 2674561 (1954-04-01), Moyer
Miller, The Journal of Organic Chemistry, vol. 28, No. 4, Apr. 1963, pp. 1148-1150.
Birkinshaw et al., Biochem J. 39, pp. 70-72, 1945.
Martin et al., J. of Bacteriol, vol. 70, 1955, pp. 405-414.

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