Methods of treating cancer and viral infections with 5-iodo-6-am

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3135

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active

057835993

ABSTRACT:
Unsubstituted or substituted 5-iodo-6-amino-1,2-benzopyrones and their metabolites are potent, selective and non-toxic inhibitors and supressants of cancer growth and viral infections in a mammalian host. The compounds are particularly useful for treatment and supression of tumors and viruses associated with AIDS, herpetic episodes and cytomegaloviral infections. The methods of treatment of tumorigenic and viral diseases by 5-iodo-6-amino-1,2-benzopyrones and/or its metabolites are described.

REFERENCES:
patent: 3974289 (1976-08-01), Buckle et al.
patent: 4012407 (1977-03-01), Doyle et al.
patent: 4032544 (1977-06-01), Doyle et al.
patent: 4382951 (1983-05-01), Grassberger
patent: 4460578 (1984-07-01), Cervelle
patent: 4550121 (1985-10-01), Pilgram et al.
patent: 4558040 (1985-12-01), Pilgram et al.
patent: 4737517 (1988-04-01), della Valle et al.
patent: 4845121 (1989-07-01), Witiak et al.
patent: 4845242 (1989-07-01), Powers
patent: 4904690 (1990-02-01), Aono
Carter et al., Chemotherapy of cancer, 2nd Ed, John Wiley & Sons, N.Y., N.Y., 1981, pp. 361-365.
1953, J. Pharm. Soc. Jap. 73:351.
1954, J. Pharm. Soc. Jap. 74:271.
Abdel-Meglid, 1977, "Heterocyclic Fluoro Compounds . . . ," Egypt. J. Chem. 20:453.
Aldovini, A. et al., 1990, "Mutations of RNA and protein sequences involved in human immunodeficiency virus Type 1 packaging result in production of noninfectious virus," J. Virol. 64:1920-1926.
Bergman, E., 1961, "Organic Fluorine Compounds," J. Chem. Soc. 4033.
Berkow, R., 1987, Editor Merck Sharp & Dohme, Rahway, NNJ, The Merck Manual 15:159, 1218, 288.
Buki, K. et al., May 30, 1991, "Destabilization of Zn(II) coordination in poly(ADP-Ribose) polymerase by 6-nitroso-1,2-bnezopyrone coincidental with inactivation of the polymerase but not with the DNA binding function," The Paul Mandel International Meeting of Poly (ADP-Ribosyl)ation Reactions, Abstract 22C.
Buki, K. et al., 1991, "Inhibitor binding of adenosine disphosphoribosyl transferase to the DNA primer site of reverse transcriptase templates," Biochem. Biophys. Res. Commun. 180:496-503.
Buki, K. et al., 1991, "Destabilization of Zn.sup.2+ coordination in ADP-ribose transferase (polymerizing) by C-nitroso-1 , 2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function," FEBS 290:181-185.
Casiraghi G., 1980, "Selective Reaction Between Phenols," J. Chem. Soc. Perkin Trans II 1862.
Chackravarti, D., 1971, "Synthesis of 3-Substituted Coumarins," J. Ind. Chem. Soc. 48:375.
Cole, G. et al., 1991, "Inhibition of HIV-1 IIIb Replication in AA-2 and MT-2 Cells in Culture by Two Ligands of Poly (ADP-ribose) Polymerase: 6-Amino-1,2 Benzopyrone and 5-IODO-6-Amino-1,2-Benzopyrone," Biochem. Biophys. Res. Commun. 180:504-514.
Elhardt, W.J. et al., 1988, "Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs," J. Med. Chem. 31:323-329.
Furlini, G. et al., 1991, "Increased poly (ADP-ribose) polymerasse activity in cells infected by human immunodeficiency virus type-1," Microbiologica 14(2):141-148.
Gopalan, 1975, "A New Synthesis of 3-methylcoumarins," Synthesis 599.
Gopalan, 1977, "A New Synthesis of 3-methylcoumarins," Synthesis 464.
Gopalan, 1978, "A New Synthesis of 3-methylcoumarins," Synthesis 144.
Gorelick, R. et al., 1988, "Point mutants of moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a zinc-finger like protein sequence," Proc. Acad. Sci. U.S.A. 85:8420-8424.
Gorelick, R. et al., 1990, "Noninfectious human immunodeficiency virus Type 1 mutants devicient in genomic RNA," J. Virol. 64:3207-3211.
Gradwohl, G. et al., 1990, "The second zinc-finger domain of poly (ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA," Proc. Natl. Acad. U.S.A. 87:2990-2994.
Hakam, A. et al., Feb. 9, 1987, "Catalytic activities of synthetic octadeoxyribonucleotides as coenzymes of poly(ADP-ribose) polymerase and the identification of a new inhibitory site," FEBS Letters 212(1):73-78.
Henderson, L. et al., 1981, "Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses," J. Biol. Chem. 256(16):8400-8403.
Ibne-Rasa, K. et al., 1982, "O-Nitrosobenzamide. A possible intermediate in the von Richter reaction," J. Org. Chem. 47(24):4664-4670.
Kirsten, E. et al., 1991, "Cellular regulation of ADP-ribosylation of proteins IV. Conversion of poly (ADP-Ribose) polymerase activity to NAD-glycohydrolase during retinoic acid-induced differentiation of HL60 cells," Experimental Cell Research 194:1-8.
Kitagawa, H., Iwaki, R., 1958, Abstract, Yakugaku Zasshi 78:491.
Kitagawa, H., Iwaki, R., 1964, "Coumarin Derivatives for Medicinal Purposes," Chem Abst. 60:15017e.
Kokotos G., Tzougraki Ch., 1986, "Synthesis and Study of Substituted Coumarins," J. Heterocyclic. Chem. 23:87.
Kondo, H., 1923, "Skraup's Guinoline Synthesis . . . . ," J. Pharm. Soc. Jap. 498-615.
Kovacic, P. et al., 1990, "Reduction potentials in relation to physiological activities of benzenoid and heterocylic nitroso compounds: comparison with the nitro precursors," Bioorganic Chemistry 18:265-275.
Krasil'Nikov, et al., 1991, "Inhibitors of ADP-ribosylation as antiviral drugs: Experimental study of the model of HIV infection," VOPR. VIRUSOL (Russia) 36(3):216-218.
Lele, S., 1958, "Iodination of 7-Hydroxy . . .," J. Org. Chem. 23:1731.
Lever, A. et al., 1989, "Identification of a sequence required for efficient packaging of human immunodeficiency virus Type 1 RNA into virions," J. Virol. 63:4085-4087.
Locke, D., 1978, Crown Publisher, Inc., NY, Virus Diseases 1-6.
McClelland, R.A. et al., 1987, "Products of the reductions of 2-nitroimidizoles," J. Am. Chem. Soc. 109:4308-4314.
Meric, C. et al., 1989, "Characterization of moloney murine leukemia virus mutants with single amino acid substitutions in the Cys-His box of the nucleocapsid protein," J. Virol. 63:1558-1568.
Mulcahy, R. T. et al., 1989, "Cytoxicity and glutahione depletioni by 1-methyl-2-nitrosoimidazole in human colon cancer cells," Biochem. Pharm. 38:1667-1671.
Noss, M.B. et al., 1988, "Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole," Biochem. Pharm. 37:2585-2593.
Noss, M.B. et al., 1989, "I-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabilities," Int. J. Radiation Oncology Biol. Phys. 16:1015-1019.
Oka, K. et al., 1969, "Fluorescent Whitening Agents . . . ," Chem. Abstr. 70:30023.
Reppel, L., 1965, "Beitrage zur Kenntnis der Cumarine," Arch. Pharm. 296:365.
Rice, W. et al., 1992, "Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly (ADP-ribose) polymerase," Proc. Natl. Acad. Sci. U.S.A. 89:7703-7707.
Sastry, S., 1990, "The Interaction of Adenosine . . . ," Biochem. Biophys. Res. Commun. 167:842.
Sastry, S. et al., 1989, "Binding of Adenosine Liphosphoribosyl Transferase," Biochemistry 28:5670.
Seidel, W. et al., 1975, "Oxidation of aromatic hydrazides," Chem. Abstr. 82:16505X.
Smith, C., 1986, "Antiviral Effect of . . . ." Proc. Natl. Acad. Sci. U.S.A. 83:2787.
South, T. et al., 1989, "113 Cd NMR studies of 1:1 Cd adduct with an 18-residue finger peptide from HIV-1 nucleic acid binding protein, p7," J. Am. Chem. Soc. 111:395-396.
South, T. et al., 1990, "Zinc fingers and molecular recognition. Structure and nucleic acid binding studies of an HIV zinc fingerlike domain," Biochem. Pharm. 40:123-129.
Stuart-Harris, 1966, "The Background to Chemotherapy of Virus Disease," Charles C. Womms Publisher, Springfield IL 76-77.
Summers, M. et al., 1990, "High-resolution structure of a HIV zinc fingerlike domain via a new NMR-based distance geometry approach," Biochemistry 29:329-340.
Tsen, A. et al., 1987, "Prevention of Tumorigenesis . . . ," Proc. Natl. Acad. Sci. U.S.A. 84:1107.
Varghese, A.J. et al., 1983, "Modification of guanine derivatives by reduced 2-nitroimidazoles," Cancer Research 43:78-82.
Wigler, M. et al., 1979, "DNA-Mediated Transfer . . . ," Proc. Natl. Acad. Sci. U.S.A. 76:1373.
Wubbels, G. et al., 1982, "Mechanism of water-catalyzed photo-isomerization of p-n

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