Spiro-substituted azacyclic-substituted piperazino derivatives a

Details Spiro-substituted azacyclic-substituted piperazino derivatives a Spiro-substituted azacyclic-substituted piperazino derivatives a

1996-12-20

1998-07-21

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142245, 540598, 544 6, 544231, 544251, 544361, 544364, 544368, 544372, A61K 31495, A61K 3154, C07D40100, C07D40300

Patent

active

057835799

ABSTRACT:
The invention relates to compounds of the formula ##STR1## wherein Z, R.sub.c, y, m, u, Ar.sub.2, n, X, R.sub.c', I and Ar.sub.2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

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Roderick et al, J. Med. Chem., 9 (1966), pp. 181-185.
Ong et al, J. Med. Chem., 26 (1983), pp. 981-986.
Yamato, et al, Chem. Pharm. Bull., 29 12 (1981), pp. 3494-3498.

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