Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositi

Details Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositi Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositi

1979-06-20

1981-03-17

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544250, 544283, 544286, 544291, 560 36, 560 37, 548311, 564384, A61K 31505, C07D48704

Patent

active

042567483

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1,R.sup.2,R.sup.3 and R.sup.4 are as hereinafter described, tautomers and salts thereof, are disclosed. The foregoing compounds inhibit the aggregation of blood platelets which renders them useful as therapeutic agents in the prophylaxis of thromboses. Furthermore, they are useful for the treatment and prophylaxis of cardiac insufficiency and cardiac failure, due to their inotropic activity without substantial tachycardia.

REFERENCES:
patent: 3932407 (1976-01-01), Beverung, Jr. et al.
patent: 3983119 (1976-09-01), Beverung, Jr. et al.
patent: 3988340 (1976-10-01), Partyka et al.
Jen et al., J. Med. Chem., vol. 15, No. 7, pp. 727-731 (1972).
Loev et al., Experientia, p. 875, (08/15/71).

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