Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-02-27
1998-07-21
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 536 232, C12N 1512, C12N 1563, C12N 1585
Patent
active
057834180
ABSTRACT:
The present invention provides a nucleic acid sequence which identifies and encodes a G protein gamma subunit (gpg) which was isolated from human pituitary gland. The invention provides for genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding GPG. The invention also provides for purified GPG.
REFERENCES:
Fisher KJ, et al. "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)." Mol. Cell. Biol. 12: 1585-1591 Apr. 1992.
Sambrook J, et al. "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor Laboratory Press, NY. 1989.
Aussel et al., J. Immunol., pp. 140:215-220 (1988).
Clapman et al., New Roles for G-protein .beta..gamma.-dimers in transmembrane signaling, Nature, 365:403-406, (1993).
Fisher et al., Characterization of the cDNA and Genomic Sequence of a G Protein .gamma.Subunit (.gamma.5), Mol. Cell. Biol., 12:1585-1591 (1992).
Iyengar, Molecular and functional diversity of mammalian G-stimulated adenylyl cyclases,FASEB Jour., 7:768-775, (1993).
Neer et al., Heterotrimeric G Proteins: Organizers of Transmembranes Signals, Cell, 80:249-257 (1995).
Stephens et al., A Novel Phosphoinositide 3 Kinase Activity in Myeloid-Derived Cells is Activated by G Protein .beta..gamma.Subunits, Cell, 77:83-93 (1994).
Watson et al., The G protein Linked Receptor Facts Book, pp. 350-355 (1994) .
Au-Young Janice
Guegler Karl J.
Murry Lynn E.
Seilhamer Jeffrey J.
Stuart Susan G.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Nelson Amy J.
Robinson Douglas W.
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