Method of detecting cytomegalovirus (CMV)

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 6, 435 71, 435 911, 435 912, 204456, 530300, 530350, 5303881, C12Q 170, C12Q 168, A61K 3800, C07K 100

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057833834

ABSTRACT:
The present invention provides methods and compositions relating to cytomegalovirus (CMV) latent transcripts, latency-associated polypeptides and antibodies directed against such polypeptide. The polypeptides are encoded by CMV DNA sequences and are produced specifically during latent infection. Also provided are methods of detecting CMV in a sample, particularly CMV in a latent state. The methods include RT-PCR-based methods and immunodiagnostic methods.

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Wu, T.-C., et al., "In situ Detection of Human Cytomegalovirus Immediate-Early Gene Transcripts within Cardiac Myocytes of Patients with HIV-Assoicated Cardiomypathy," AIDS 6:777 (1992).
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Lehner, R., et al., "Comparative Sequence Analysis of Human Cytomegalovirus Strains," Journal of Clinical Microbiology 29(11): 2494-2502 (1991).
Tamashiro, J.C., et al., "Structure of Heterogeneous L-S Junction Region of Human Cytolmegalovirus Strain AD169 DNA," Journal of Virology 52(2): 541-548 (1984).

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